Professor Layton is back with a puzzling prequel. The start of a second trilogy the the adventures of Professor Layton, the story for this fourth DS Layton game kicks off three years prior to the events of the original Professor Layton and the Curious Village. Professor Layton, visiting the mysterious "city of mist," comes into the acquaintance of a young Luke for the first time. He also meets Remi Altiwa, a new heroine. The three embark on a quest surrounding the legend of a giant that threatens to destroy the city. Professor Layton and the Last Specter connects directly to the Layton movie, so fans of the series get the complete story first in the game and then continued in the events of the movie.

Professor Layton receives a letter asking for help from Luke. The strange thing is that this letter is from 10 years in the future, and the Luke in question is not Professor Layton’s young apprentice, but rather his older self. According to the future Luke, the London of the future has been brought to the brink of ruin by Professor Layton’s future self, who is the head of the largest crime syndicate in town. It seems the only man who can save London and stop the evil Professor Layton of the future is Professor Layton himself.

In the world of Professor Layton, puzzles hide in every corner. When the professor's mentor is mysteriously murdered, a cursed artifact called the Elysian Box appears to be behind it. With a ticket to the Molentary Express as their only lead, Professor Layton and Luke embark on an adventure that will test their wits and work their brains. Calling all brainteaser fans! With tons of in-game puzzles of different types and difficulties, there's something for everyone from kids to adults. As Professor Layton, you'll open doors with sliding puzzles, uncover clues with logic puzzles, and find answers by solving riddles. A cinematic experience! This large-scale sequel to Professor Layton and the Curious Village™ features three times the voiced dialogue and movies of its predecessor. The fully voiced movies, hand-drawn art style, and cast of eccentric characters bring the story to life and are sure to charm puzzle fans young and old.