Following the death of his wife, Rachel, Rayleigh Stern spent the next six months in therapy group, trying to find ways to cope. Having lost the love of his life to cancer; he's ready to throw in the towel. Group therapy isn't helping, and he's had enough.

Then, on his last group session, he encounters a beautiful young woman waiting to see a drug counselor in the lobby of the office where his group meets. The two become acquainted, and against all his willpower, he begins to fall for the girl despite her young age, sexual orientation, and drug addiction.

While romance is not in the cards for the two of them, they miraculously become entwined in something even deeper and more sacred than romantic love. Winifred refers to their relationship and all the ensuing synchronicity in their lives as ''God Shots,'' a concept Rayleigh initially dismisses but later begins to understand.

As they discover incredible truths about themselves, their unlikely friendship begins to transform both their lives in ways they could never have imagined.